Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F13%3A43896716" target="_blank" >RIV/60461373:22310/13:43896716 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00213-012-2797-7" target="_blank" >http://dx.doi.org/10.1007/s00213-012-2797-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00213-012-2797-7" target="_blank" >10.1007/s00213-012-2797-7</a>

Result language

angličtina

Original language name

Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats

Original language description

Rationale and objectives Behavioral, neurochemical and pharmaco-EEG profiles of a new synthetic drug 4-bromo- 2,5-dimethoxyphenethylamine (2C-B) in rats were examined. Materials and methods Locomotor effects, prepulse inhibition (PPI) of acoustic startlereaction (ASR), dopamine and its metabolite levels in nucleus accumbens (NAc), EEG power spectra and coherence in freely moving rats were analysed. Amphetamine was used as a reference compound. Results 2C-B had a biphasic effect on locomotion with initial inhibitory followed by excitatory effect; amphetamine induced only hyperlocomotion. Both drugs induced deficits in the PPI; however they had opposite effects on ASR. 2C-B increased dopamine but decreased 3,4-dihydroxyphenylacetic acid (DOPAC) in the NAc. Low doses of 2C-B induced a decrease in EEG power spectra and coherence. On the contrary, high dose of 2C-B 50 mg/kg had a temporally biphasic effect with an initial decrease followed by an increase in EEG power; decrease as well as i

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NT13843" target="_blank" >NT13843: The influence of immune system dysregulation and latent toxoplasmosis on brain morphology in schizophrenia: animal models and a prospective volumetric study in patients</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychopharmacology

ISSN

1432-2072

e-ISSN

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Volume of the periodical

225

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

18

Pages from-to

75-93

UT code for WoS article

000313163900007

EID of the result in the Scopus database

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