Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB/c mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43906988" target="_blank" >RIV/00216208:11120/13:43906988 - isvavai.cz</a>

Alternative codes found

RIV/61388971:_____/13:00426449 RIV/61383082:_____/13:0034

Result on the web

<a href="http://dx.doi.org/10.1111/imm.12007" target="_blank" >http://dx.doi.org/10.1111/imm.12007</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/imm.12007" target="_blank" >10.1111/imm.12007</a>

Result language

angličtina

Original language name

Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB/c mice

Original language description

Several studies have documented that dietary modifications influence the development of type 1 diabetes. However, little is known about the interplay of dietary components and the penetration of diabetes incidence. In this study we tested if wheat glutenis able to induce differences in the cytokine pattern of Foxp3+ regulatory T cells, as well as Foxp3- T cells, isolated from intestinal mucosal lymphoid tissue and non-mucosal lymphoid compartments in BALB/c mice. The gluten-containing standard diet markedly changed the cytokine expression within Foxp3- T cells, in all lymphoid organs tested, towards a higher expression of pro-inflammatory interferon-? (IFN-?), interleukin-17 (IL-17) and IL-2. In Foxp3+ regulatory T cells, gluten ingestion resulted ina mucosal increase in IL-17 and IL-2 and an overall increase in IFN-? and IL-4. The gluten-free diet induced an anti-inflammatory cytokine profile with higher proportion of transforming growth factor-beta (TGF-beta)+Foxp3- T cells in all

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Immunology

ISSN

0019-2805

e-ISSN

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Volume of the periodical

138

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

23-33

UT code for WoS article

000312537100003

EID of the result in the Scopus database

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