Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F14%3A43908150" target="_blank" >RIV/00216208:11120/14:43908150 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/14:10210611 RIV/00064203:_____/14:10210611
Result on the web
<a href="http://dx.doi.org/10.1016/j.jcf.2013.06.003" target="_blank" >http://dx.doi.org/10.1016/j.jcf.2013.06.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jcf.2013.06.003" target="_blank" >10.1016/j.jcf.2013.06.003</a>

Result language
angličtina
Original language name
Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations
Original language description
In recent years different IRT/PAP protocols have been evaluated, but the individual performance remains unclear. To optimize the IRT/PAP strategy we compared protocols from three regional CF newborn screening centers (Heidelberg, Dresden, and Prague). Methods: We evaluated the effect of elevating the IRT-cut-off from 50 to 65 mu g/l (similar to 97.5th to similar to 99.0th percentile), the need of a failsafe protocol (FS, lRT >= 99.9th percentile) and the relative performance using either two lRT-dependent PAP-cut-offs or one PAP-cut-off. Findings: Elevation of the IRT cut-off to 65 mu g/l (similar to 99.0th percentile) increased the PPV significantly (Dresden: 0.065 vs. 0.080, p <0.0001, Prague: 0.052 vs. 0.074, p <0.0001) without reducing sensitivity.All three IRT/PAP protocols showed a trend towards a higher sensitivity with FS than without and when using one PAP-cut-off instead of two IRT-dependent PAP-cut-offs. Conclusions: For best performance we suggest an IRT/PAP protocol with
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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