Prevention or Early Cure of Type 1 Diabetes by Intranasal Administration of Gliadin in NOD Mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F14%3A43908572" target="_blank" >RIV/00216208:11120/14:43908572 - isvavai.cz</a>

Alternative codes found

RIV/61383082:_____/14:#0000262

Result on the web

<a href="http://dx.doi.org/10.1371/journal.pone.0094530" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0094530</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0094530" target="_blank" >10.1371/journal.pone.0094530</a>

Result language

angličtina

Original language name

Prevention or Early Cure of Type 1 Diabetes by Intranasal Administration of Gliadin in NOD Mice

Original language description

Induction of long-term tolerance to beta-cell autoantigens has been investigated both in animal models and in human type 1 diabetes (T1D) in order to prevent the disease. As regards external compounds, the dietary plant protein fraction has been associated with high penetrance of the disease, whereas gluten-free diets prevent T1D in animal models. Herewith we investigated whether intranasal (i.n.) administration of gliadin or gluten may arrest the diabetogenic process. I.n. administration of gliadin to4-week-old NOD mice significantly reduced the diabetes incidence. Similarly, the insulitis was lowered. Intranasal gliadin also rescued a fraction of prediabetic 13-week-old NOD mice from progressing to clinical onset of diabetes compared to OVA-treatedcontrols. Vaccination with i.n. gliadin led to an induction of CD4(+)Foxp3(+) T cells and even more significant induction of gamma delta T cells in mucosal, but not in non-mucosal lymphoid compartments. This prevention strategy was charac

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS One

ISSN

1932-6203

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

"e94530; 1-10"

UT code for WoS article

000336736200090

EID of the result in the Scopus database

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