Circulating tumour cells in patients with urothelial tumours: Enrichment and in vitro culture

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F14%3A43909166" target="_blank" >RIV/00216208:11120/14:43909166 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.5489/cuaj.1978" target="_blank" >http://dx.doi.org/10.5489/cuaj.1978</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5489/cuaj.1978" target="_blank" >10.5489/cuaj.1978</a>

Result language
angličtina
Original language name
Circulating tumour cells in patients with urothelial tumours: Enrichment and in vitro culture
Original language description
INTRODUCTION: Results of clinical trials have demonstrated that circulating tumour cells (CTCs) are frequently detected in patients with urothelial tumours. The monitoring of CTCs has the potential to improve therapeutic management at an early stage andalso to identify patients with increased risk of tumour progression or recurrence before the onset of clinically detected metastasis. In this study, we report a new effectively simplified methodology for a separation and in vitro culturing of viable CTCsfrom peripheral blood. METHOD: We include patients diagnosed with 3 types of urothelial tumours (prostate cancer, urinary bladder cancer, and kidney cancer). A size-based separation method for viable CTC - enrichment from unclothed peripheral blood hasbeen introduced (MetaCell, Ostrava, Czech Republic). The enriched CTCs fraction was cultured directly on the separation membrane, or transferred from the membrane and cultured on any plastic surface or a microscopic slide. RESULTS: We rep
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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