Cancer prevention and therapy through the modulation of the tumor microenvironment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909622" target="_blank" >RIV/00216208:11120/15:43909622 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.semcancer.2015.02.007" target="_blank" >http://dx.doi.org/10.1016/j.semcancer.2015.02.007</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.semcancer.2015.02.007" target="_blank" >10.1016/j.semcancer.2015.02.007</a>

Result language

angličtina

Original language name

Cancer prevention and therapy through the modulation of the tumor microenvironment

Original language description

Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve dynamically through indirect and direct cellular interactions, eliciting multiscaleeffects on many biological programs, including cellular proliferation, growth, and metabolism, as well as angiogenesis and hypoxia and innate and adaptive immunity. Here we highlight specific biological processes that could be exploited as targets for the prevention and therapy of cancer. Specifically, we describe how inhibition of targets such as cholesterol synthesis and metabolites, reactive oxygen species and hypoxia, macrophage activation and conversion, indoleamine 2,3-dioxygenase regulation of dendritic cells, vascular endothelial growth factor regulation of angiogenesis, fibrosis inhibition, endoglin, and Janus kinase signaling emerge as examples of important potential nexuses in the regulation of tumorigenesis and the tumor mic

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Seminars in Cancer Biology

ISSN

1044-579X

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

Suppl.

Country of publishing house

GB - UNITED KINGDOM

Number of pages

25

Pages from-to

"S199"-"S223"

UT code for WoS article

000366619400010

EID of the result in the Scopus database

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