Oleyl-hyaluronan micelles loaded with upconverting nanoparticles for bio-imaging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43910336" target="_blank" >RIV/00216208:11120/15:43910336 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s11051-015-3186-z" target="_blank" >http://dx.doi.org/10.1007/s11051-015-3186-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11051-015-3186-z" target="_blank" >10.1007/s11051-015-3186-z</a>
Alternative languages
Result language
angličtina
Original language name
Oleyl-hyaluronan micelles loaded with upconverting nanoparticles for bio-imaging
Original language description
Hyaluronan (HA) represents an interesting polymer for nanoparticle coating due to its biocompatibility and enhanced cell interaction via CD44 receptor. Here, we describe incorporation of oleate-capped beta-NaYF4:Yb3+, Er3+ nanoparticles (UCNP-OA) into amphiphilic HA by microemulsion method. Resulting structures have a spherical, micelle-like appearance with a hydrodynamic diameter of 180 nm. UCNP-OA-loaded HA micelles show a good stability in PBS buffer and cell culture media. The intensity of green emission of UCNP-OA-loaded HA micelles in water is about five times higher than that of ligand-free UCNP, indicating that amphiphilic HA effectively protects UCNP luminescence from quenching by water molecules. We found that UCNP-OA-loaded HA micelles in concentrations up to 50 mu g mL(-1) increase cell viability of normal human dermal fibroblasts (NHDF), while viability of human breast adenocarcinoma cells MDA-MB-231 is reduced at these concentrations. The utility of UCNP-OA-loaded HA mice
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Nanoparticle Research
ISSN
1388-0764
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
9
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
11
Pages from-to
"Article ID 383"
UT code for WoS article
000361882700001
EID of the result in the Scopus database
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