Expression of HLA-DQA1 and HLA-DQB1 genes in B lymphocytes, monocytes and whole blood
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43916648" target="_blank" >RIV/00216208:11120/18:43916648 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1111/iji.12367" target="_blank" >https://doi.org/10.1111/iji.12367</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/iji.12367" target="_blank" >10.1111/iji.12367</a>
Alternative languages
Result language
angličtina
Original language name
Expression of HLA-DQA1 and HLA-DQB1 genes in B lymphocytes, monocytes and whole blood
Original language description
Differential expression of HLA-DQA1 and HLA-DQB1 gene alleles was analysed in three different cell populations isolated from peripheral blood-B lymphocytes, monocytes and whole-blood cells. Interallelic differences in mRNA levels were observed: DQA1*03 alleles were among the most expressed in all cell types, whereas DQA1*05 alleles were least expressed in whole blood and monocytes and among the most expressed in B cells. For DQB1 gene, DQB1*06 group of alleles were the most expressed, and DQB1*02 group the least expressed within all cell populations examined. In comparison with the rest alleles, DQB1*06 and DQB1*05:02 alleles have higher expression in monocytes than in B cells, professional antigen-presenting cells. Cell type-specific regulation of expression was observed as well, with higher and more balanced expression of alleles in B lymphocytes compared to monocytes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Immunogenetics
ISSN
1744-3121
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
128-137
UT code for WoS article
000433577800005
EID of the result in the Scopus database
2-s2.0-85047919902