Proconvulsant effects induced by pyridoxine in young rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F98%3A43903519" target="_blank" >RIV/00216208:11120/98:43903519 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/S0920-1211(97)00088-0" target="_blank" >http://dx.doi.org/10.1016/S0920-1211(97)00088-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/S0920-1211(97)00088-0" target="_blank" >10.1016/S0920-1211(97)00088-0</a>

Result language
angličtina
Original language name
Proconvulsant effects induced by pyridoxine in young rats
Original language description
High doses of pyridoxine (vitamin B6) can be neurotoxic in adults. Effects of intraperitoneally administered B6 (100, 250 and 400 mg/kg) were studied in 7, 12, 18 and 60 day old rats. B6 elicited epileptiform EEG discharges without any motor correlate in all age groups. In contrast, motor seizures were rare, seen only in 18 day old rats (250 mg/kg of B6). Data indicate that in young rats, B6 may have proconvulsant effects in doses relevant to those sometimes used in pediatric neurology
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
<a href="/en/project/IZ3613" target="_blank" >IZ3613: Effects of repeated seizures and long-term antiepileptic therapy on brain morphology and function</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
1998
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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