Anticonvulsant and behavioral effects of muscimol in immature rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F14%3A10293074" target="_blank" >RIV/00216208:11130/14:10293074 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/14:00434399

Result on the web

<a href="http://dx.doi.org/10.1016/j.brainres.2014.07.038" target="_blank" >http://dx.doi.org/10.1016/j.brainres.2014.07.038</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.brainres.2014.07.038" target="_blank" >10.1016/j.brainres.2014.07.038</a>

Result language

angličtina

Original language name

Anticonvulsant and behavioral effects of muscimol in immature rats

Original language description

Potentiation of GABAergic inhibition is a mechanism of action of many antiepileptic drugs. The potential use of an agonist of GABA-A receptors, muscimol, as an antiepileptic drug was studied in immature rats by assessing anticonvulsant activity and sideeffects on motor activities. Anticonvulsant action was tested in two models of seizures (pentetrazol-induced convulsions and cortical epileptic afterdischarges). Off target effect on motor performance was assessed in a battery of tests and in the open field in three age groups (12-, 18- and 25-day-old rats). Muscimol was administered in doses from 0.1 to 1 mg/kg i.p. Only the 1 mg/kg dose exhibited marked anticonvulsant effect against pentetrazol-induced convulsions in 12- and 18-day-old rats, proconvulsant effect was observed in the second model in 18- and 25-day-old rats as prolongation of afterdischarges. Even the 0.5 mg/kg dose suppressed spontaneous locomotion and heavily compromised motor performance. The effect on motor activity

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/GAP304%2F10%2F1274" target="_blank" >GAP304/10/1274: Drugs influencing GABA-B receptors in pediatric medicine</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Brain Research

ISSN

0006-8993

e-ISSN

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Volume of the periodical

1582

Issue of the periodical within the volume

neuveden

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

227-236

UT code for WoS article

000343357100022

EID of the result in the Scopus database

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