Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00438420" target="_blank" >RIV/67985823:_____/14:00438420 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.pharep.2014.02.018" target="_blank" >http://dx.doi.org/10.1016/j.pharep.2014.02.018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.pharep.2014.02.018" target="_blank" >10.1016/j.pharep.2014.02.018</a>

Result language
angličtina
Original language name
Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP
Original language description
Action of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. Dorsal hippocampus of rat pups 12, 18 and 25 days old was stimulated six times with 10-min intervals. MTEP (20 or 40 mg/kg) wasinjected after the first afterdischarge and duration of afterdischarges was measured.MTEP exhibited marked anticonvulsant action in 12-day-old-rats, the similar effect in 18-day-old rats was observed only with the second stimulation. No anticonvulsant action was seen in 25-day-old animals.Our results may qualify antagonists of mGluR5 as potential antiepileptic drugs for some types of childhood epilepsies
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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