Age- and Sex-Related Characteristics of Tonic Gaba Currents in the Rat Substantia Nigra Pars Reticulata
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10294505" target="_blank" >RIV/00216208:11130/15:10294505 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/15:10294505
Result on the web
<a href="http://dx.doi.org/10.1007/s11064-015-1523-3" target="_blank" >http://dx.doi.org/10.1007/s11064-015-1523-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11064-015-1523-3" target="_blank" >10.1007/s11064-015-1523-3</a>
Alternative languages
Result language
angličtina
Original language name
Age- and Sex-Related Characteristics of Tonic Gaba Currents in the Rat Substantia Nigra Pars Reticulata
Original language description
Previous studies have shown that the pharmacologic effects of GABAergic drugs and the postsynaptic phasic GABA(A)ergic inhibitory responses in the anterior part of the rat substantia nigra pars reticulata (SNRA) are age- and sex-specific. Here, we investigate whether there are age- and sex-related differences in the expression of the delta GABA(A) receptor (GABA(A)R) subunit and GABA(A)R mediated tonic currents. We have used delta-specific immunochemistry and whole cell patch clamp to study GABA(A)R mediated tonic currents in the SNRA of male and female postnatal day (PN) PN5-9, PN11-16, and PN25-32 rats. We observed age-related decline, but no sex-specific changes, in bicuculline (BIM) sensitive GABA(A)R tonic current density, which correlated with the decline in delta subunit in the SNRA between PN15 and 30. Furthermore, we show that the GABA(A)R tonic currents can be modified by muscimol (GABA(A)R agonist; partial GABA(C)R agonist), THIP (4,5,6,7-tetrahydroisoxazolo (5,4-c)pyridin-3
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GD309%2F08%2FH079" target="_blank" >GD309/08/H079: PhD program in neuroscience</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neurochemical Research
ISSN
0364-3190
e-ISSN
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Volume of the periodical
40
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
747-757
UT code for WoS article
000351861100012
EID of the result in the Scopus database
2-s2.0-84939975788