Alzheimer's Disease: Mechanism and Approach to Cell Therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10315607" target="_blank" >RIV/00216208:11130/15:10315607 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/15:00450243
Result on the web
<a href="http://dx.doi.org/10.3390/ijms161125961" target="_blank" >http://dx.doi.org/10.3390/ijms161125961</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms161125961" target="_blank" >10.3390/ijms161125961</a>
Alternative languages
Result language
angličtina
Original language name
Alzheimer's Disease: Mechanism and Approach to Cell Therapy
Original language description
Alzheimer's disease (AD) is the most common form of dementia. The risk of AD increases with age. Although two of the main pathological features of AD, amyloid plaques and neurofibrillary tangles, were already recognized by Alois Alzheimer at the beginning of the 20th century, the pathogenesis of the disease remains unsettled. Therapeutic approaches targeting plaques or tangles have not yet resulted in satisfactory improvements in AD treatment. This may, in part, be due to early-onset and late-onset AD pathogenesis being underpinned by different mechanisms. Most animal models of AD are generated from gene mutations involved in early onset familial AD, accounting for only 1% of all cases, which may consequently complicate our understanding of AD mechanisms. In this article, the authors discuss the pathogenesis of AD according to the two main neuropathologies, including senescence-related mechanisms and possible treatments using stem cells, namely mesenchymal and neural stem cells.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
11
Country of publishing house
CH - SWITZERLAND
Number of pages
35
Pages from-to
26417-26451
UT code for WoS article
000365648300031
EID of the result in the Scopus database
2-s2.0-84946594802