Basal forebrain atrophy contributes to allocentric navigation impairment in alzheimer's disease patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10315982" target="_blank" >RIV/00216208:11130/15:10315982 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/15:00063292 RIV/00064203:_____/15:10315982

Result on the web

<a href="http://dx.doi.org/10.3389/fnagi.2015.00185" target="_blank" >http://dx.doi.org/10.3389/fnagi.2015.00185</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnagi.2015.00185" target="_blank" >10.3389/fnagi.2015.00185</a>

Result language

angličtina

Original language name

Basal forebrain atrophy contributes to allocentric navigation impairment in alzheimer's disease patients

Original language description

The basal forebrain degenerates in Alzheimer's disease (AD) and this process is believed to contribute to the cognitive decline observed in AD patients. Impairment in spatial navigation is an early feature of the disease but whether basal forebrain dysfunction in AD is responsible for the impaired navigation skills of AD patients is not known. Our objective was to investigate the relationship between basal forebrain volume and performance in real space as well as computer-based navigation paradigms in an elderly cohort comprising cognitively normal controls, subjects with amnestic mild cognitive impairment and those with AD. We also tested whether basal forebrain volume could predict the participants' ability to perform allocentric- vs. egocentric-based navigation tasks. The basal forebrain volume was calculated from 1.5 T magnetic resonance imaging (MRI) scans, and navigation skills were assessed using the human analog of the Morris water maze employing allocentric, egocentric, and mi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Aging Neuroscience

ISSN

1663-4365

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

září

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

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UT code for WoS article

000362361700001

EID of the result in the Scopus database

2-s2.0-84946569908