The Common Follicle-Stimulating Hormone Receptor (FSHR) Promoter Polymorphism FSHR-29G> A Affects Androgen Production in normal Human Small Antral Follicles

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373800" target="_blank" >RIV/00216208:11130/17:10373800 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/17:10373800

Result on the web

<a href="https://doi.org/10.3389/fendo.2017.00122" target="_blank" >https://doi.org/10.3389/fendo.2017.00122</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fendo.2017.00122" target="_blank" >10.3389/fendo.2017.00122</a>

Result language

angličtina

Original language name

The Common Follicle-Stimulating Hormone Receptor (FSHR) Promoter Polymorphism FSHR-29G> A Affects Androgen Production in normal Human Small Antral Follicles

Original language description

Follicle-stimulating hormone receptors (FSHRs) are almost exclusively expressed on granulosa cells, and FSH action is probably most clearly reflected in intrafollicular hormone milieu of antral follicles. Little is known about the possible effects of the common single nucleotide polymorphism (SNP) FSHR -29G &gt; A (rs1394205) on hormonal conditions in humsan small antral follicles (hSAFs) obtained from women in the natural menstrual cycle. This study investigated the follicle fluid (FF) concentrations of anti-Mullerian hormone, estradiol, progesterone, androstenedione, and testosterone in hSAF in relation to the different genotypes of FSHR -29G &gt; A. FF from 362 follicles was collected in 95 women undergoing fertility preservation, who did not suffer from a disease that directly affected ovarian function. The testosterone levels of the minor A/A genotype were significantly increased compared to the A/G and the G/G genotype. Furthermore, significantly reduced androstenedione levels were observed for the G/G genotype, as compared to the A/G genotype, while the other hormones did not show statistical significant differences. In conclusion, the androgen levels of hSAF were significantly elevated in the minor SNP genotype in the FSHR promoter polymorphism FSHR -29G &gt; A.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10600 - Biological sciences

Project

<a href="/en/project/NT13770" target="_blank" >NT13770: Examination of DNA instability in gametes, embryos and somatic cells following oncological therapy for improvement of reproductive success in treated patients.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Endocrinology

ISSN

1664-2392

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

June

Country of publishing house

CH - SWITZERLAND

Number of pages

6

Pages from-to

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UT code for WoS article

000402505400001

EID of the result in the Scopus database

2-s2.0-85020546477