The polymorphic insertion of the luteinizing hormone receptor "insLQ" show a negative association to LHR gene expression and to the follicular fluid hormonal profile in human small antral follicles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10375387" target="_blank" >RIV/00216208:11130/18:10375387 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/18:10375387
Result on the web
<a href="https://doi.org/10.1016/j.mce.2017.07.002" target="_blank" >https://doi.org/10.1016/j.mce.2017.07.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mce.2017.07.002" target="_blank" >10.1016/j.mce.2017.07.002</a>
Alternative languages
Result language
angličtina
Original language name
The polymorphic insertion of the luteinizing hormone receptor "insLQ" show a negative association to LHR gene expression and to the follicular fluid hormonal profile in human small antral follicles
Original language description
The luteinizing hormone receptor (LHCGR) has a little studied polymorphic 6 bp insertion (rs4539842/insLQ). This study has evaluated the insLQ polymorphism in relation to potential associations with hormonal characteristics of human small antral follicles (hSAFs). In total, 310 hSAFs were collected from 86 women undergoing fertility preservation. Analysis included hormonal profile of 297 follicular fluid (FF) samples and 148 corresponding granulosa cells samples were evaluated by cPCR for selected genes. Significantly reduced and non-detectable mRNA levels of anti-Mullerian hormone receptor II (AMHR2) and LHCGR, respectively, were observed for insLQ]insLQ compared to -/insLQ and the -/- genotypes. Moreover, LHCGR and CYP19a1 together with oestradiol and inhibin-B were significantly increased in -/insLQ compared to the -/- genotype. The homozygous insLQ genotype showed strong significant associations to GC specific genes LHCGR and CYP19a1, which may translate into significant changes in FF hormone profiles and an altered LH signaling.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10600 - Biological sciences
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular and Cellular Endocrinology
ISSN
0303-7207
e-ISSN
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Volume of the periodical
460
Issue of the periodical within the volume
15
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
6
Pages from-to
57-62
UT code for WoS article
000423893300006
EID of the result in the Scopus database
2-s2.0-85024474722