Effect of Balanced Crystalloid, Gelatin and Hydroxyethyl Starch on Coagulation Detected by Rotational Thromboelastometry In Vitro

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373879" target="_blank" >RIV/00216208:11130/17:10373879 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/17:10373879

Result on the web

<a href="https://doi.org/10.7754/Clin.Lab.2017.170505" target="_blank" >https://doi.org/10.7754/Clin.Lab.2017.170505</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7754/Clin.Lab.2017.170505" target="_blank" >10.7754/Clin.Lab.2017.170505</a>

Result language

angličtina

Original language name

Effect of Balanced Crystalloid, Gelatin and Hydroxyethyl Starch on Coagulation Detected by Rotational Thromboelastometry In Vitro

Original language description

Background: Fluid resuscitation with crystalloid and colloid solutions is a common treatment in perioperative medicine. However, a variety of unbalanced or balanced solutions are used in clinical practice and there is still vivid debate going on regarding selection of optimal fluid with minimal negative effect on coagulation to minimize bleeding and blood transfusion requirements. The aim of the study was to investigate adverse effects of balanced crystalloids and colloids on coagulation measured by thromboelastometry in vitro. Methods: Blood samples were obtained from healthy volunteers undergoing knee arthroscopy. Adverse effects of balanced crystalloid, hydroxyethyl starch, and gelatin were evaluated by thromboelastometry after 20% dilution of blood with the solution in vitro. Parameters of EXTEM and FIBTEM test were evaluated. Results: Clotting time of EXTEM was not significantly influenced by any of the investigated solutions (p &gt; 0.05). However, significant impairment of clot formation time of EXTEM was detected in hydroxyethyl starch and gelatin groups in comparison with controls (p &lt; 0.05), while crystalloid did not affect this parameter significantly (p &gt; 0.05). Similar results were found in a angle although significant coagulopathy effect was found only in hydroxyethyl starch samples (p &lt; 0.05). Maximum clot firmness of EXTEM and FIBTEM tests was significantly affected by both hydroxyethyl starch and gelatin (p &lt; 0.05) but not by crystalloid. Conclusions: Balanced crystalloid solution does not seem to have a negative influence on the coagulation process as measured by thromboelastometry. On the other hand, balanced colloids may impair propagation phase of coagulation, strength of coagulum, and level of functional fibrinogen. Hydroxyethyl starch seems to have a stronger anticoagulant effect compared to gelatin.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30223 - Anaesthesiology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Laboratory

ISSN

1433-6510

e-ISSN

—

Volume of the periodical

63

Issue of the periodical within the volume

10

Country of publishing house

DE - GERMANY

Number of pages

10

Pages from-to

1691-1700

UT code for WoS article

000413571800018

EID of the result in the Scopus database

2-s2.0-85032736238