Rotational thromboelastometry assessment of ballanced crystalloid, hydroxyethyl starch and gelatin effects on coagulation: a randomized trial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F19%3A10395903" target="_blank" >RIV/00064203:_____/19:10395903 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/19:10395903

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=SrH2x4D1JC" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=SrH2x4D1JC</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bjan.2019.03.009" target="_blank" >10.1016/j.bjan.2019.03.009</a>

Result language

angličtina

Original language name

Rotational thromboelastometry assessment of ballanced crystalloid, hydroxyethyl starch and gelatin effects on coagulation: a randomized trial

Original language description

Background and objectives: Modern crystalloid and colloid solutions are balanced solutions which are increasingly used in perioperative period. However, studies investigating their negative effect on whole blood coagulation are missing, and vivid debate is going on about which solution has the minimal coagulopathy effect. The aim of our study was to assess the effect of modern fluid solutions on whole blood coagulation using rotational thromboelastometry. Methods: Blood samples were obtained from 30 patients during knee arthroscopy before and after administration of 500 mL of crystalloid, Hydroxyethyl Starch and gelatin according to the randomization. Rotational thromboelastometry (Extem, Intem and Fibtem tests) was used to assess negative effect of fluid solutions on whole blood coagulation. Results: In Extem test, the initiation phase of fibrin clot formation represented by CT parameter was not influenced by any fluid solution (p &gt; 0.05). The speed of clot formation represented by CFT and α angle was impaired by Hydroxyethyl Starch and gelatin but not by crystalloids (p &lt; 0.05). The strength of formatted coagulum represented by MCF parameter was impaired both in Extem and Fibtem test by HES and in Fibtem also by crystalloids (p &lt; 0.05). Intem test was not negatively influenced by any crystalloid or colloid solution in any parameter (p &gt; 0.05). Conclusion: Extem test appears to be sensitive to coagulopathy effect of modern colloids and crystalloids. Hydroxyethyl starch has the most obvious negative effect on clot formation followed by gelatin and finally by crystalloids. Intem test seems to be insensitive to adverse effect of modern colloids and crystalloids.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30223 - Anaesthesiology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Revista Brasileira de Anestesiologia

ISSN

0034-7094

e-ISSN

—

Volume of the periodical

69

Issue of the periodical within the volume

4

Country of publishing house

BR - BRAZIL

Number of pages

7

Pages from-to

383-389

UT code for WoS article

000486332500008

EID of the result in the Scopus database

2-s2.0-85070234119