Effect of Selected Crystalloid and Colloid Solutions on Coagulation Status Evaluated by Rotational Thromboelastometry and Platelet Function Analyser: An in vitro Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10487493" target="_blank" >RIV/00064203:_____/25:10487493 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/25:10487493

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=I2h9P~IBjt" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=I2h9P~IBjt</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000541772" target="_blank" >10.1159/000541772</a>

Result language

angličtina

Original language name

Effect of Selected Crystalloid and Colloid Solutions on Coagulation Status Evaluated by Rotational Thromboelastometry and Platelet Function Analyser: An in vitro Study

Original language description

Introduction: Crystalloid and colloid solutions commonly used in intensive and perioperative care can affect haemocoagulation status. This in vitro study assessed the impact of Plasma-Lyte, albunorm 5%, and Gelaspan 4% solutions on primary and secondary haemostasis using rotational thromboelastometry and platelet function analyser. Methods: In this prospective study, we examined blood samples from 20 healthy volunteers using rotational thromboelastometry and platelet function analyser. Simultaneously, we analysed the blood samples subjected to 10% dilution using Plasma-Lyte, albunorm 5%, and Gelaspan 4% solutions. Results: Compared to controls, Plasma-Lyte shortened EXTEM-CT (p = 0.005) and reduced FIBTEM-MCF (p = 0.017). albunorm 5% prolonged EXTEM-CFT (p = 0.001), decreased EXTEM-alpha (p &lt; 0.001) and MCF in EXTEM, INTEM, and FIBTEM tests (p &lt; 0.001, p = 0.038, p = 0.001, respectively), along with MCE in the PLTEM test (p &lt; 0.001). Gelaspan 4% also prolonged EXTEM-CFT (p &lt; 0.001), decreased EXTEM-alpha (p &lt; 0.001) and MCF in EXTEM, INTEM, and FIBTEM tests (p &lt; 0.001, p &lt; 0.001, p = 0.009, respectively), along with MCE in the PLTEM test (p &lt; 0.001). Gelaspan 4% also reduced EXTEM-CT (p = 0.021). All solution prolonged CT in PFA Col/ADP (p = 0.003 for Plasma-Lyte, p &lt; 0.001 for albunorm and Gelaspan) and albunorm 5% also prolonged CT in Col/Epi (p = 0.003). Conclusion: Plasma-Lyte had the least effect on secondary haemostasis, whereas albunorm 5% had the least effect among colloids. Gelaspan 4% adversely affected the propagation phase of coagulation, maximal strength and elasticity of the coagulum, and the level of functional fibrinogen. All solutions adversely affected platelet function in primary haemostasis, with Plasma-Lyte showing the least effect.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30223 - Anaesthesiology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Transfusion Medicine and Hemotherapy

ISSN

1660-3796

e-ISSN

1660-3818

Volume of the periodical

52

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

132-141

UT code for WoS article

001346207900001

EID of the result in the Scopus database

2-s2.0-85208560283