Melanoma during pregnancy: a report of 60 pregnancies complicated by melanoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373916" target="_blank" >RIV/00216208:11130/17:10373916 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/17:10373916
Result on the web
<a href="https://doi.org/10.1097/CMR.0000000000000327" target="_blank" >https://doi.org/10.1097/CMR.0000000000000327</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/CMR.0000000000000327" target="_blank" >10.1097/CMR.0000000000000327</a>
Alternative languages
Result language
angličtina
Original language name
Melanoma during pregnancy: a report of 60 pregnancies complicated by melanoma
Original language description
The management of melanoma during pregnancy is challenging as maternal benefits and fetal risks need to be balanced. Here, we present an overview of the incidence, the demographic and clinical characteristics and the treatment modalities used. After analysis of obstetric, fetal and maternal outcome, recommendations for clinical practice are provided. From the 'International Network on Cancer, Infertility and Pregnancy' database, pregnant patients with melanoma were identified and analysed. Sixty pregnancies were eligible for analysis. Fifty percent of the patients presented with advanced melanoma during pregnancy (14 stage III and 16 stage IV), and 27% were diagnosed with recurrent melanoma. Surgery was the main therapeutic strategy during pregnancy. Only four patients with advanced melanoma were treated during pregnancy with systemic therapy (n=1) or radiotherapy (n=3). Premature delivery was observed in 18% of the ongoing pregnancies, all which were induced and 78% of which involved patients with advanced melanoma. Thirty-nine percent of the patients died within 5 years; all had been diagnosed with stage III or IV disease during pregnancy. Melanoma can present in a more advanced stage during pregnancy. New systemic therapies may be beneficial for patients with metastatic melanoma but may not be pregnancy compatible. In these patients, preterm induction of labour need to be discussed, despite the short-term and long-term negative effects on the child.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Melanoma Research
ISSN
0960-8931
e-ISSN
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Volume of the periodical
27
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
218-223
UT code for WoS article
000400502300006
EID of the result in the Scopus database
2-s2.0-85009789137