A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10392688" target="_blank" >RIV/00216208:11130/17:10392688 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/17:00481621
Result on the web
<a href="https://doi.org/10.1038/s41467-017-01283-z" target="_blank" >https://doi.org/10.1038/s41467-017-01283-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-017-01283-z" target="_blank" >10.1038/s41467-017-01283-z</a>

Result language
angličtina
Original language name
A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
Original language description
Astrocyte responses to neuronal injury may be beneficial or detrimental to neuronal recovery, but the mechanisms that determine these different responses are poorly understood. Here we show that ephrin type-B receptor 1 (EphB1) is upregulated in injured motor neurons, which in turn can activate astrocytes through ephrin-B1-mediated stimulation of signal transducer and activator of transcription-3 (STAT3). Transcriptional analysis shows that EphB1 induces a protective and anti-inflammatory signature in astrocytes, partially linked to the STAT3 network. This is distinct from the response evoked by interleukin (IL)-6 that is known to induce both pro inflammatory and anti-inflammatory processes. Finally, we demonstrate that the EphB1-ephrin-B1 pathway is disrupted in human stem cell derived astrocyte and mouse models of amyotrophic lateral sclerosis (ALS). Our work identifies an early neuronal help-me signal that activates a neuroprotective astrocytic response, which fails in ALS, and therefore represents an attractive therapeutic target.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30103 - Neurosciences (including psychophysiology)

Project
<a href="/en/project/GA17-21146S" target="_blank" >GA17-21146S: Evaluation of ion channels and receptors in human neural progenitors derived from induced pluripotent stem cells during motoneuronal differentiation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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