A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00481621" target="_blank" >RIV/68378041:_____/17:00481621 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/17:10392688
Result on the web
<a href="http://dx.doi.org/10.1038/s41467-017-01283-z" target="_blank" >http://dx.doi.org/10.1038/s41467-017-01283-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-017-01283-z" target="_blank" >10.1038/s41467-017-01283-z</a>
Alternative languages
Result language
angličtina
Original language name
A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
Original language description
Astrocyte responses to neuronal injury may be beneficial or detrimental to neuronal recovery, but the mechanisms that determine these different responses are poorly understood. Here we show that ephrin type-B receptor 1 (EphB1) is upregulated in injured motor neurons, which in turn can activate astrocytes through ephrin-B1-mediated stimulation of signal transducer and activator of transcription-3 (STAT3). Transcriptional analysis shows that EphB1 induces a protective and anti-inflammatory signature in astrocytes, partially linked to the STAT3 network. This is distinct from the response evoked by interleukin (IL)-6 that is known to induce both pro inflammatory and anti-inflammatory processes. Finally, we demonstrate that the EphB1-ephrin-B1 pathway is disrupted in human stem cell derived astrocyte and mouse models of amyotrophic lateral sclerosis (ALS). Our work identifies an early neuronal help-me signal that activates a neuroprotective astrocytic response, which fails in ALS, and therefore represents an attractive therapeutic target.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/GA17-21146S" target="_blank" >GA17-21146S: Evaluation of ion channels and receptors in human neural progenitors derived from induced pluripotent stem cells during motoneuronal differentiation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Communications
ISSN
2041-1723
e-ISSN
—
Volume of the periodical
8
Issue of the periodical within the volume
oct.
Country of publishing house
GB - UNITED KINGDOM
Number of pages
17
Pages from-to
—
UT code for WoS article
000413833000008
EID of the result in the Scopus database
2-s2.0-85032486894