Surface Microdialysis for Detection of Colorectal Anastomosis Ischemia—An Experimental Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F21%3A10458381" target="_blank" >RIV/00216208:11130/21:10458381 - isvavai.cz</a>

Alternative codes found

RIV/67985904:_____/21:00541962 RIV/00023001:_____/21:00080673

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9xCcw-P5WX" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9xCcw-P5WX</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jss.2020.12.021" target="_blank" >10.1016/j.jss.2020.12.021</a>

Result language

angličtina

Original language name

Surface Microdialysis for Detection of Colorectal Anastomosis Ischemia—An Experimental Study

Original language description

Background: Inadequate blood supply is one of the major risk factors for anastomotic leak after low anterior rectal resection. Early detection of ischemia might predict complicated healing and enable anastomotic salvage, which is associated with better outcomes. A microdialysis offers a real-time evaluation of adequate bowel perfusion through moni-toring of tissue metabolism. In this experimental study, we assessed the role of micro-dialysis in detecting early ischemia after colorectal anastomosis. Materials and methods: Colorectal anastomosis was performed in six miniature pigs. A microdialysis catheter was placed on the bowel serosa 5 mm proximal to the anastomosis. Metabolic changes were monitored hourly before and after initiating ischemia, which was induced by ligation of the inferior mesenteric artery and skeletonization of the mesocolon. Results: Significant increase in tissue levels of lactate was detected after 60 min of ischemia (13.6 [10.4-16.1] versus 6.75 [1.8-9.6] mmol/L at baseline; P &lt; 0.005). The lactate/pyruvate ratio increased accordingly. The concentration of glycerol increased significantly after 2 hoursdfrom a baseline value of 29.5 (3-84) to 125 (79-201) mmol/L (P &lt; 0.005). The decrease in glucose levels was also significant after 60 minutesd0 (0-0.2) versus 4.7 (3.3-6.8) mmol/L at baseline. However, its values started to decline before ischemia. Conclusions: Surface microdialysis can detect ischemic changes early and may be a prom-ising method in postoperative monitoring of colorectal anastomosis.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30212 - Surgery

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Surgical Research

ISSN

0022-4804

e-ISSN

1095-8673

Volume of the periodical

261

Issue of the periodical within the volume

May

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

293-300

UT code for WoS article

000635161100037

EID of the result in the Scopus database

2-s2.0-85099367416