Surface Microdialysis for Detection of Colorectal Anastomosis Ischemia - An Experimental Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F21%3A00541962" target="_blank" >RIV/67985904:_____/21:00541962 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/21:00080673 RIV/00216208:11130/21:10458381
Result on the web
<a href="https://asep.lib.cas.cz/arl-cav/cs/csg/?repo=crepo1&key=6396274089" target="_blank" >https://asep.lib.cas.cz/arl-cav/cs/csg/?repo=crepo1&key=6396274089</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jss.2020.12.021" target="_blank" >10.1016/j.jss.2020.12.021</a>
Alternative languages
Result language
angličtina
Original language name
Surface Microdialysis for Detection of Colorectal Anastomosis Ischemia - An Experimental Study
Original language description
Background: Inadequate blood supply is one of the major risk factors for anastomotic leak after low anterior rectal resection. Early detection of ischemia might predict complicated healing and enable anastomotic salvage, which is associated with better outcomes. A microdialysis offers a real-time evaluation of adequate bowel perfusion through moni-toring of tissue metabolism. In this experimental study, we assessed the role of micro-dialysis in detecting early ischemia after colorectal anastomosis.nMaterials and methods: Colorectal anastomosis was performed in six miniature pigs. A microdialysis catheter was placed on the bowel serosa 5 mm proximal to the anastomosis. Metabolic changes were monitored hourly before and after initiating ischemia, which was induced by ligation of the inferior mesenteric artery and skeletonization of the mesocolon. Results: Significant increase in tissue levels of lactate was detected after 60 min of ischemia (13.6 [10.4-16.1] versus 6.75 [1.8-9.6] mmol/L at baseline, P < 0.005). The lactate/pyruvate ratio increased accordingly. The concentration of glycerol increased significantly after 2 hoursdfrom a baseline value of 29.5 (3-84) to 125 (79-201) mmol/L (P < 0.005). The decrease in glucose levels was also significant after 60 minutesd0 (0-0.2) versus 4.7 (3.3-6.8) mmol/L at baseline. However, its values started to decline before ischemia.nConclusions: Surface microdialysis can detect ischemic changes early and may be a prom-ising method in postoperative monitoring of colorectal anastomosis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30212 - Surgery
Result continuities
Project
<a href="/en/project/NV16-31806A" target="_blank" >NV16-31806A: New methods of in vivo monitoring and management of colonic anastomosis leak in experimental model</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Surgical Research
ISSN
0022-4804
e-ISSN
1095-8673
Volume of the periodical
261
Issue of the periodical within the volume
MAY
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
293-300
UT code for WoS article
000635161100037
EID of the result in the Scopus database
2-s2.0-85099367416