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Surface Microdialysis for Detection of Colorectal Surface Microdialysis for Detection of Colorectal

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F21%3A00001051" target="_blank" >RIV/61383082:_____/21:00001051 - isvavai.cz</a>

  • Result on the web

    <a href="https://pubmed.ncbi.nlm.nih.gov/33477078/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/33477078/</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jss.2020.12.021" target="_blank" >10.1016/j.jss.2020.12.021</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Surface Microdialysis for Detection of Colorectal Surface Microdialysis for Detection of Colorectal

  • Original language description

    Background: Inadequate blood supply is one of the major risk factors for anastomotic leak after low anterior rectal resection. Early detection of ischemia might predict complicated healing and enable anastomotic salvage, which is associated with better outcomes. A microdialysis offers a real-time evaluation of adequate bowel perfusion through moni toring of tissue metabolism. In this experimental study, we assessed the role of micro dialysis in detecting early ischemia after colorectal anastomosis.Materials and methods: Colorectal anastomosis was performed in six miniature pigs. A microdialysis catheter was placed on the bowel serosa 5 mm proximal to the anastomosis. Metabolic changes were monitored hourly before and after initiating ischemia, which was induced by ligation of the inferior mesenteric artery and skeletonization of the mesocolon. Results: Significant increase in tissue levels of lactate was detected after 60 min of ischemia (13.6 [10.4-16.1] versus 6.75 [1.8-9.6] mmol/L at baseline; P < 0.005). The lactate/pyruvate ratio increased accordingly. The concentration of glycerol increased significantly after 2 hoursdfrom a baseline value of 29.5 (3-84) to 125 (79-201) mmol/L (P < 0.005). The decrease in glucose levels was also significant after 60 minutesd0 (0-0.2) versus 4.7 (3.3-6.8) mmol/L at baseline. However, its values started to decline before ischemia. Conclusions: Surface microdialysis can detect ischemic changes early and may be a prom ising method in postoperative monitoring of colorectal anastomosis

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30212 - Surgery

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    JOURNAL OF SURGICAL RESEARCH

  • ISSN

    0022-4804

  • e-ISSN

  • Volume of the periodical

    261

  • Issue of the periodical within the volume

    May

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    293-300

  • UT code for WoS article

    000635161100037

  • EID of the result in the Scopus database