Response to NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F22%3A10441719" target="_blank" >RIV/00216208:11130/22:10441719 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9x90uxXEo_" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9x90uxXEo_</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.stemcr.2022.02.007" target="_blank" >10.1016/j.stemcr.2022.02.007</a>
Alternative languages
Result language
angličtina
Original language name
Response to NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation
Original language description
In our recent publication in Stem Cell Reports (Lobo de Figueiredo-Pontes et al., 2021), we assessed the role of NK cells on hematopoietic stem cell (HSC) fate during HSC transplantation and concluded that NK cells, possibly via secretion of cytokines (and in particular IFNγ), negatively affect HSC frequency and function. In their letter in this issue of Stem Cell Reports, Merli and colleagues report carrying out an interesting attempt to translate our observations to clinics (Merli et al., 2022). They performed a retrospective analysis of 2 cohorts of pediatric patients transplanted after ex vivo T cell depletion (Locatelli et al., 2017; Merli et al., 2021; Lang et al., 2014) and concluded that the amount of NK cells in the graft does not have an impact in the transplantation outcome. While we acknowledge the value of their analysis, we believe that there are critical factors between both studies that prevent Merli et al. from reaching our same conclusions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Stem Cell Reports
ISSN
2213-6711
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
2
Pages from-to
446-447
UT code for WoS article
000767602800002
EID of the result in the Scopus database
2-s2.0-85125618242