Liquid resorbable nanofibrous surgical mesh: a proof of a concept
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F22%3A10442872" target="_blank" >RIV/00216208:11130/22:10442872 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/22:10442872 RIV/00216208:11110/22:10442872 RIV/00216208:11510/22:10442872
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=dUaY2G3I1G" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=dUaY2G3I1G</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10029-022-02582-1" target="_blank" >10.1007/s10029-022-02582-1</a>
Alternative languages
Result language
angličtina
Original language name
Liquid resorbable nanofibrous surgical mesh: a proof of a concept
Original language description
BACKGROUND: Surgical mesh is widely used not only to treat but also to prevent incisional hernia formation. Despite much effort by material engineers, the 'ideal' mesh mechanically, biologically and surgically easy to use remains elusive. Advances in tissue engineering and nanomedicine have allowed new concepts to be tested with promising results in both small and large animals. Abandoning the concept of a pre-formed mesh completely for a 'pour in liquid mesh' has never been tested before. MATERIALS AND METHODS: Thirty rabbits underwent midline laparotomy with closure using an absorbable suture and small stitch small bites technique. In addition, their abdominal wall closure was reinforced by a liquid nanofibrous scaffold composed of a fibrin sealant and nanofibres of poly-ε-caprolactone with or without hyaluronic acid or the sealant alone, poured in as an 'onlay' over the closed abdominal wall. The animals were killed at 6 weeks and their abdominal wall was subjected to histological and biomechanical evaluations. RESULTS: All the animals survived the study period with no major complication. Histological evaluation showed an eosinophilic infiltration in all groups and foreign body reaction more pronounced in the groups with nanofibres. Biomechanical testing demonstrated that groups treated with nanofibres developed a scar with higher tensile yield strength. CONCLUSION: The use of nanofibres in a liquid form applied to the closed abdominal wall is easy to use and improves the biomechanical properties of healing fascia at 6 weeks after midline laparotomy in a rabbit model.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30212 - Surgery
Result continuities
Project
<a href="/en/project/NV17-32285A" target="_blank" >NV17-32285A: Functionalized nanofibers for prevention of incisional hernia formation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Hernia [online]
ISSN
1248-9204
e-ISSN
1248-9204
Volume of the periodical
26
Issue of the periodical within the volume
2
Country of publishing house
IT - ITALY
Number of pages
9
Pages from-to
557-565
UT code for WoS article
000778070900001
EID of the result in the Scopus database
2-s2.0-85127383730