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Liquid resorbable nanofibrous surgical mesh: a proof of a concept

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F22%3A00569559" target="_blank" >RIV/68378041:_____/22:00569559 - isvavai.cz</a>

  • Alternative codes found

    RIV/62157124:16170/22:43879951 RIV/68407700:21720/22:00358431 RIV/68407700:21460/22:00358431

  • Result on the web

    <a href="https://link.springer.com/article/10.1007/s10029-022-02582-1" target="_blank" >https://link.springer.com/article/10.1007/s10029-022-02582-1</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s10029-022-02582-1" target="_blank" >10.1007/s10029-022-02582-1</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Liquid resorbable nanofibrous surgical mesh: a proof of a concept

  • Original language description

    Background Surgical mesh is widely used not only to treat but also to prevent incisional hernia formation. Despite much effort by material engineers, the 'ideal' mesh mechanically, biologically and surgically easy to use remains elusive. Advances in tissue engineering and nanomedicine have allowed new concepts to be tested with promising results in both small and large animals. Abandoning the concept of a pre-formed mesh completely for a 'pour in liquid mesh' has never been tested before. Materials and methods Thirty rabbits underwent midline laparotomy with closure using an absorbable suture and small stitch small bites technique. In addition, their abdominal wall closure was reinforced by a liquid nanofibrous scaffold composed of a fibrin sealant and nanofibres of poly-epsilon-caprolactone with or without hyaluronic acid or the sealant alone, poured in as an 'onlay' over the closed abdominal wall. The animals were killed at 6 weeks and their abdominal wall was subjected to histological and biomechanical evaluations. Results All the animals survived the study period with no major complication. Histological evaluation showed an eosinophilic infiltration in all groups and foreign body reaction more pronounced in the groups with nanofibres. Biomechanical testing demonstrated that groups treated with nanofibres developed a scar with higher tensile yield strength. Conclusion The use of nanofibres in a liquid form applied to the closed abdominal wall is easy to use and improves the biomechanical properties of healing fascia at 6 weeks after midline laparotomy in a rabbit model.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30404 - Biomaterials (as related to medical implants, devices, sensors)

Result continuities

  • Project

    <a href="/en/project/NV17-32285A" target="_blank" >NV17-32285A: Functionalized nanofibers for prevention of incisional hernia formation</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Hernia

  • ISSN

    1265-4906

  • e-ISSN

    1248-9204

  • Volume of the periodical

    26

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    FR - FRANCE

  • Number of pages

    9

  • Pages from-to

    557-565

  • UT code for WoS article

    000778070900001

  • EID of the result in the Scopus database

    2-s2.0-85127383730