Liquid resorbable nanofibrous surgical mesh: a proof of a concept

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F22%3A00569559" target="_blank" >RIV/68378041:_____/22:00569559 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/22:43879951 RIV/68407700:21720/22:00358431 RIV/68407700:21460/22:00358431

Result on the web

<a href="https://link.springer.com/article/10.1007/s10029-022-02582-1" target="_blank" >https://link.springer.com/article/10.1007/s10029-022-02582-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10029-022-02582-1" target="_blank" >10.1007/s10029-022-02582-1</a>

Result language

angličtina

Original language name

Liquid resorbable nanofibrous surgical mesh: a proof of a concept

Original language description

Background Surgical mesh is widely used not only to treat but also to prevent incisional hernia formation. Despite much effort by material engineers, the 'ideal' mesh mechanically, biologically and surgically easy to use remains elusive. Advances in tissue engineering and nanomedicine have allowed new concepts to be tested with promising results in both small and large animals. Abandoning the concept of a pre-formed mesh completely for a 'pour in liquid mesh' has never been tested before. Materials and methods Thirty rabbits underwent midline laparotomy with closure using an absorbable suture and small stitch small bites technique. In addition, their abdominal wall closure was reinforced by a liquid nanofibrous scaffold composed of a fibrin sealant and nanofibres of poly-epsilon-caprolactone with or without hyaluronic acid or the sealant alone, poured in as an 'onlay' over the closed abdominal wall. The animals were killed at 6 weeks and their abdominal wall was subjected to histological and biomechanical evaluations. Results All the animals survived the study period with no major complication. Histological evaluation showed an eosinophilic infiltration in all groups and foreign body reaction more pronounced in the groups with nanofibres. Biomechanical testing demonstrated that groups treated with nanofibres developed a scar with higher tensile yield strength. Conclusion The use of nanofibres in a liquid form applied to the closed abdominal wall is easy to use and improves the biomechanical properties of healing fascia at 6 weeks after midline laparotomy in a rabbit model.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30404 - Biomaterials (as related to medical implants, devices, sensors)

Project

<a href="/en/project/NV17-32285A" target="_blank" >NV17-32285A: Functionalized nanofibers for prevention of incisional hernia formation</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Hernia

ISSN

1265-4906

e-ISSN

1248-9204

Volume of the periodical

26

Issue of the periodical within the volume

2

Country of publishing house

FR - FRANCE

Number of pages

9

Pages from-to

557-565

UT code for WoS article

000778070900001

EID of the result in the Scopus database

2-s2.0-85127383730