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Calcined Hydroxyapatite with Collagen I Foam Promotes Human MSC Osteogenic Differentiation

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F22%3A10443085" target="_blank" >RIV/00216208:11130/22:10443085 - isvavai.cz</a>

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=t9vbTC6E16" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=t9vbTC6E16</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/ijms23084236" target="_blank" >10.3390/ijms23084236</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Calcined Hydroxyapatite with Collagen I Foam Promotes Human MSC Osteogenic Differentiation

  • Original language description

    Collagen I-based foams were modified with calcined or noncalcined hydroxyapatite or calcium phosphates with various particle sizes and pores to monitor their effect on cell interactions. The resulting scaffolds thus differed in grain size, changing from nanoscale to microscopic, and possessed diverse morphological characteristics and resorbability. The materials&apos; biological action was shown on human bone marrow MSCs. Scaffold morphology was identified by SEM. Using vi-ability test, qPCR, and immunohistochemical staining, we evaluated the biological activity of all of the materials. This study revealed that the most suitable scaffold composition for osteogenesis induction is collagen I foam with calcined hydroxyapatite with a pore size of 360+-130 µm and mean particle size of 0.130 µm. The expression of osteogenic markers RunX2 and ColI mRNA was pro-moted, and a strong synthesis of extracellular protein osteocalcin was observed. ColI/calcined HAP scaffold showed significant osteogenic potential, and can be easily manipulated and tailored to the defect size, which gives it great potential for bone tissue engineering applications.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10610 - Biophysics

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Molecular Sciences

  • ISSN

    1661-6596

  • e-ISSN

  • Volume of the periodical

    23

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    17

  • Pages from-to

    4236

  • UT code for WoS article

    000786142100001

  • EID of the result in the Scopus database

    2-s2.0-85127855615