Intracerebellar application of P19-derived neuroprogenitor and naive stem cells to Lurcher mutant and wild type B6CBA mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F12%3A10123254" target="_blank" >RIV/00216208:11140/12:10123254 - isvavai.cz</a>

Alternative codes found

RIV/49777513:23420/12:43917280 RIV/00216224:14310/12:00107128

Result on the web

<a href="http://dx.doi.org/" target="_blank" >http://dx.doi.org/</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Intracerebellar application of P19-derived neuroprogenitor and naive stem cells to Lurcher mutant and wild type B6CBA mice

Original language description

Background: Neurotransplantation has great potential for future treatments of various neurodegenerative disorders. Preclinically, the Lurcher mutant mouse represents an appropriate model of genetically-determined olivocerebellar degeneration. The aim ofthe present study was to assess survival of naive and neurally differentiated P19 carcinoma stem cells following transplantation into the cerebellum of Lurcher mice and wild type littermates.Material/Methods: Adult normal wild type (n=51) and Lurcher mutant mice (n=87) of the B6CBA strain were used. The mean age of the animals at the time of transplantation was 261.5 days. Suspension of naive and neurally differentiated P19 carcinoma stem cells was injected into the cerebellum of the mice. In the Lurcher mutants, 2 depths of graft injection were used. Three weeks after implantation the brains of experimental animals were examined histologically. Results: Survival of neuroprogenitor grafts at a depth of 1.6 mm was significantly higher in

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/OC10038" target="_blank" >OC10038: Transplantation of the embryonic cerebellar tissue and stem cells into the cerebellum of Lurcher mutant and normal mice</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medical Science Monitor

ISSN

1234-1010

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

5

Country of publishing house

PL - POLAND

Number of pages

7

Pages from-to

"BR174"-"BR180"

UT code for WoS article

000304535900003

EID of the result in the Scopus database

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