Interleukin-8 (CXCL8) in tumor associated non-vascular extracellular fluids: its diagnostic and prognostic values. A review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F12%3A10123892" target="_blank" >RIV/00216208:11140/12:10123892 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.5301/JBM.2012.9261" target="_blank" >http://dx.doi.org/10.5301/JBM.2012.9261</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5301/JBM.2012.9261" target="_blank" >10.5301/JBM.2012.9261</a>

Result language

angličtina

Original language name

Interleukin-8 (CXCL8) in tumor associated non-vascular extracellular fluids: its diagnostic and prognostic values. A review

Original language description

Interleukin-8 (IL-8, CXCL8) was originally discovered as a powerful attractor and activator of polymorphonuclear leukocytes. It was soon recognized that IL-8 also affects proliferation and migration of cancer cells, tumor angiogenesis and metastasis, andthat it is expressed in many cancerous cell types. IL-8 protein expression is usually increased in serum of cancer patients, but markedly higher concentrations are found in cancer-associated non-vascular extracellular fluids, such as pleural effusion, ascites and cyst fluid. Elevated concentrations of IL-8 are indicative of malignant processes also in cerebrospinal fluid, urine, saliva, interstitial fluid and cervicovaginal secretions. Higher IL-8 levels are typically found in high-grade peritumoral fluids rather than low-grade tumors and benign conditions, with the exception of inflammatory processes. In line with recent molecular biology investigations, it appears that the local IL-8 production is related to its malignant origin and

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Biological Markers

ISSN

0393-6155

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

3

Country of publishing house

IT - ITALY

Number of pages

10

Pages from-to

"e169"-"e178"

UT code for WoS article

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EID of the result in the Scopus database

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