Histology of ventral abdominal incisions in a porcine model - in vivo experiment with incorporation of artificial meshes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F12%3A10191822" target="_blank" >RIV/00216208:11140/12:10191822 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Histology of ventral abdominal incisions in a porcine model - in vivo experiment with incorporation of artificial meshes
Original language description
We examined the tissue reaction to incorporation of two types of artificial tissue-engineered meshes in porcine abdominal wall after 6 and 12 weeks of regeneration. Using six quantitative histological parameters, the area fraction of type I collagen, actin-positive smooth muscle cells and myofibroblasts, and the microvessel density was assessed in the healing incision and 2 cm laterally from the incision. From histological point of view, both types of scaffolds were well and uniformly integrated withinthe collagenous connective tissue of the healing incision. The presence of both types of scaffolds led to increased amount of contractile myofibroblasts within the healing incision, but the amount of microvessels in samples with scaffolds was comparablewith samples without scaffolds. In one of these scaffolds, the microvessel density was positively correlated with the fraction of type I collagen.
Czech name
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Czech description
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Publication year
2012
Confidentiality
C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.

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