Histology of abdominal incisions in rabbit - in vivo experiment with incorporation of PCL and PCL/PVA-based artificial meshes enriched with PRP

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10313899" target="_blank" >RIV/00216208:11140/15:10313899 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Histology of abdominal incisions in rabbit - in vivo experiment with incorporation of PCL and PCL/PVA-based artificial meshes enriched with PRP
Original language description
Using quantitative histology, the fraction of type I collagen, the fraction of actin-positive myofibroblasts, and the density of CD31-positive microvessel profiles were compared in samples of healing abdominal wall in rabbit. In two groups, the healing was supported by combinations of PCL+PRP or PCL/PVA+PRP artificial tissue-engineered meshes. The third group was healing spontaneously. No quantitative differences in type I collagen fraction, myofibroblasts, or microvessel density were found when comparing all the groups under study. Qualitatively, the incision supported with scaffolds formed a more regularly arranged wound with more equally distributed collagen than found in samples without scaffolds. Under both types of scaffolds, granular connectivetissue with many microvessels and collagen formation was found. The remnants of the PCL+PRP scaffolds showed a better integration of newly formed collagen than the PCL/PVA+PRP scaffolds. However, similar total amounts of collagen were fou
Czech name
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Czech description
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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