Immunodominant Semen Proteins II: Contribution of Seminal Proteins to Female Immune Infertility

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10159255" target="_blank" >RIV/00216208:11140/13:10159255 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22330/13:43895535

Result on the web

<a href="http://fb.cuni.cz/file/5701/FB2013A0028.pdf" target="_blank" >http://fb.cuni.cz/file/5701/FB2013A0028.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Immunodominant Semen Proteins II: Contribution of Seminal Proteins to Female Immune Infertility

Original language description

The aim of our work is to detect and identify seminal proteins that are related to female isoimmunization. In this report, we quantified serum anti-seminal IgG antibodies. Seminal proteins were analysed by twodimensional gel electrophoresis followed by immunoblotting. To identify IgG-binding proteins of interest, a proteomic approach was selected. The dominant seminal antigens were detected within the relative molecular mass ranging from 25 to 85 kDa and the isoelectric point from 5 to 7. The detected proteins were further identified as prostate-specific antigen, prostatic acid phosphatase, zinc-?-2-glycoprotein and zinc finger protein 778. Since these proteins were recognized by IgGs produced by infertile women and not by fertile women, we presume that major seminal antigens may play an important role in the pathogenesis of female immune infertility. Our study suggests the pattern of seminal proteins for further therapeutic attempts in the diagnosis of female immune infertility.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

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Project

<a href="/en/project/IAA600110902" target="_blank" >IAA600110902: Influence of ingestion of anthropogenically contaminated soils by heavy metals on changes of biochemical and physiological parameters of rats</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica

ISSN

0015-5500

e-ISSN

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Volume of the periodical

59

Issue of the periodical within the volume

5

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

198-203

UT code for WoS article

000327577300004

EID of the result in the Scopus database

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