Immunodominant Semen Proteins III: IgG1 and IgG4 Linkage in Female Immune Infertility

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10292610" target="_blank" >RIV/00216208:11140/15:10292610 - isvavai.cz</a>

Result on the web

<a href="http://jjbs.hu.edu.jo/files/v8n1/Paper%20Number%203m.pdf" target="_blank" >http://jjbs.hu.edu.jo/files/v8n1/Paper%20Number%203m.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Immunodominant Semen Proteins III: IgG1 and IgG4 Linkage in Female Immune Infertility

Original language description

Generated antibodies in the process of isoimmunization seem to be associated with female immune infertility. The aim of our study consists in the profiling of specific serum immunoglobulin classes and subclasses in infertile women. We focus on the distribution of serum seminal/sperm-specific antibodies in order to find those apparently related to female isoimmunization. Immunoglobulins G1-4, A1,2, M and E were measured by ELISA in serum from 30 infertile and 10 fertile females. Anti-seminal/sperm IgG1 and IgG4 fractions were predominantly detected. Anti-seminal IgG1 and IgG4 were observed approximately in the 2:1 ratio, anti-sperm fraction in the 1:2 ratio. Strikingly, the approximate ratio between IgG1 and IgG2 was 3:1 in seminal specific and 2:1 in sperm specific antibodies. Surprisingly, IgG3 antibodies were nearly negative for both antigen fractions, seminal and sperm. Concerning our results, the proportionality does exist between seminal and sperm antibody fractions. Based on the

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Jordan Journal of Biological Sciences

ISSN

1995-6673

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

1

Country of publishing house

JO - JORDAN

Number of pages

5

Pages from-to

17-21

UT code for WoS article

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EID of the result in the Scopus database

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