The role of whiskers in compensation of visual deficit in a mouse model of retinal degeneration

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10159501" target="_blank" >RIV/00216208:11140/14:10159501 - isvavai.cz</a>

Result on the web

<a href="http://ac.els-cdn.com/S0304394013009968/1-s2.0-S0304394013009968-main.pdf?_tid=0e04558e-67c7-11e3-8c6f-00000aab0f02&acdnat=1387359218_d15396f359a5d395760128caf32ef683" target="_blank" >http://ac.els-cdn.com/S0304394013009968/1-s2.0-S0304394013009968-main.pdf?_tid=0e04558e-67c7-11e3-8c6f-00000aab0f02&acdnat=1387359218_d15396f359a5d395760128caf32ef683</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neulet.2013.11.005" target="_blank" >10.1016/j.neulet.2013.11.005</a>

Result language

angličtina

Original language name

The role of whiskers in compensation of visual deficit in a mouse model of retinal degeneration

Original language description

Sensory deprivation in one modality can enhance the development of the remaining modalities via mech-anisms of synaptic plasticity. Mice of the C3H strain suffer from RD1 retinal degeneration that leads tovisual impairment at weaning age. We examined a role of whiskers in compensation of the visual deficit.In order to differentiate the contribution of the whiskers from other mechanisms that can take part in thecompensation, we investigated the effect of both chronic and acute tactile deprivation. Three-month-oldmice were used. We examined motor skills (rotarod, beam walking test), gait control (CatWalk system),spontaneous motor activity (open field) and CNS excitability to an acoustic stimulus for assessment ofcompensatory changes in auditory system (audiogenic epilepsy). In the sighted mice, the only effect was adecline in their rotarod test performance after acute whisker removal. In the blind animals, chronic tactiledeprivation caused changes in their gait and impaired the performan

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/ED2.1.00%2F03.0076" target="_blank" >ED2.1.00/03.0076: Biomedical Centre of the Faculty of Medicine in Pilsen</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroscience Letters

ISSN

0304-3940

e-ISSN

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Volume of the periodical

558

Issue of the periodical within the volume

January

Country of publishing house

IE - IRELAND

Number of pages

5

Pages from-to

149-153

UT code for WoS article

000338481300028

EID of the result in the Scopus database

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