Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10281845" target="_blank" >RIV/00216208:11140/14:10281845 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1038/ng.3096" target="_blank" >http://dx.doi.org/10.1038/ng.3096</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/ng.3096" target="_blank" >10.1038/ng.3096</a>

Result language

angličtina

Original language name

Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands

Original language description

Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functionalstudies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Genetics

ISSN

1061-4036

e-ISSN

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Volume of the periodical

46

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

1166-1169

UT code for WoS article

000344131900006

EID of the result in the Scopus database

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