In vitro testing of immunosupressive effects of mesenchymal stromal cells on lymphocytes stimulated with alloantigens

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10139963" target="_blank" >RIV/00216208:11140/15:10139963 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/15:10139963

Result on the web

<a href="http://dx.doi.org/10.5507/bp.2013.072" target="_blank" >http://dx.doi.org/10.5507/bp.2013.072</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2013.072" target="_blank" >10.5507/bp.2013.072</a>

Result language

angličtina

Original language name

In vitro testing of immunosupressive effects of mesenchymal stromal cells on lymphocytes stimulated with alloantigens

Original language description

Aims. Mesenchymal stromal cells (MSC) derived from adult bone marrow or adipose tissue offer the potential to open a new frontier in medicine. MSC are involved in modulating immune response and tissue repair in vitro and in vivo. Experimental evidence and preliminary clinical studies have demonstrated that MSC exhibit an important immunomodulatory function in patients with graft versus host disease (GVHD) following allogeneic hematopoietic stem cell transplantation. The immunosuppressive properties of MSC have already been exploited in the clinical setting. However the precise mechanisms are being still investigated. Methods. We examined the immunosuppressive function of MSC by coculturing them with stimulated HLA incompatible allogeneic lymphocytes ina mixed lymphocyte culture test. The metabolic and proliferative activity of lymphocytes was determined by MTT test. Results. After stimulation with alloantigens the presence of MSC caused significant decrease of absorbance levels by 62%

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

<a href="/en/project/ED2.1.00%2F03.0076" target="_blank" >ED2.1.00/03.0076: Biomedical Centre of the Faculty of Medicine in Pilsen</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, CzechoSK

ISSN

1213-8118

e-ISSN

—

Volume of the periodical

159

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

215-219

UT code for WoS article

000359128900008

EID of the result in the Scopus database

2-s2.0-84934290503