Trilobolide-porphyrin conjugates: On synthesis and biological effects evaluation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10282770" target="_blank" >RIV/00216208:11140/15:10282770 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22330/14:43897195 RIV/61388963:_____/15:00444157
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0039128X14002219" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0039128X14002219</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.steroids.2014.08.024" target="_blank" >10.1016/j.steroids.2014.08.024</a>
Alternative languages
Result language
angličtina
Original language name
Trilobolide-porphyrin conjugates: On synthesis and biological effects evaluation
Original language description
Trilobolide (Tb), a potent natural counterpart of thapsigargin, is a sesquiterpene lactone of guaianolide type isolated from horse caraway (Laser trilobum, L. Borkh). Since it is well known that porphyrins are preferentially taken up by cancer cells, wehave designed and synthesized novel Tb-porphyrin conjugates. Copper-catalyzed azide-alkyne cycloaddition was used to link Tb with porphyrin at once. Two model conjugates of Tb and porphyrin were synthesized and properly characterized. Employing naturallyoccurring fluorescence properties of porphyrins, we investigated the intracellular localization of the conjugates employing fluorescence microscopy in living cells. Intriguingly, the prepared conjugates localized both in mitochondria and lysosomes of HeLa and LNCaP cells. Furthermore, the cytotoxicity of Tb-porphyrin conjugates was assessed in a number of human cancer cell lines and rat peritoneal cells. Likewise in cancer cell lines, viability of rat peritoneal cells was not affected b
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Steroids
ISSN
0039-128X
e-ISSN
—
Volume of the periodical
97
Issue of the periodical within the volume
May
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
8-12
UT code for WoS article
000353178800003
EID of the result in the Scopus database
2-s2.0-84925460002