Association between endothelial NO synthase polymorphisms and arterial properties in the general population
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10290175" target="_blank" >RIV/00216208:11140/15:10290175 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1089860314005060" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1089860314005060</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.niox.2014.11.016" target="_blank" >10.1016/j.niox.2014.11.016</a>
Alternative languages
Result language
angličtina
Original language name
Association between endothelial NO synthase polymorphisms and arterial properties in the general population
Original language description
Objective Nitric oxide plays an important role in vascular biology. Several single nucleotide polymorphisms (SNP) in the endothelial nitric oxide gene (NOS3) have been previously associated with arterial hypertension. We investigated whether these SNPs might be associated with arterial phenotypes in the Czech general population. Methods We genotyped three NOS3 SNPs in 426 subjects not treated for arterial hypertension (mean age, 49.1 years; 55.9% women). Arterial properties were measured using applanation tonometry. In multivariate-adjusted analyses, we assessed the gene effects of rs3918226 (MINUS SIGN 665 C > T), rs1799983 (glu298asp G > T) and rs2070744 (786 T > C) on augmentation index (AIx), central augmentation pressure (AP) and aortic pulse wavevelocity (PWV). Results Carriers of rs3918226 mutated T allele had marginally higher AIx (145.3 +- 2.5 vs. 140.2 +- 1.1%; P = 0.064) and significantly higher AP (12.7 +- 0.7 vs. 11.1 +- 0.3 mm Hg; P = 0.033). These associations were inde
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nitric Oxide - Biology and Chemistry
ISSN
1089-8603
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
January
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
47-51
UT code for WoS article
000348694800008
EID of the result in the Scopus database
2-s2.0-84916910778