Association between endothelial NO synthase polymorphism (rs3918226) and arterial properties
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10138982" target="_blank" >RIV/00216208:11140/13:10138982 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/13:10138982
Result on the web
<a href="http://dx.doi.org/10.1016/j.artres.2012.11.002" target="_blank" >http://dx.doi.org/10.1016/j.artres.2012.11.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.artres.2012.11.002" target="_blank" >10.1016/j.artres.2012.11.002</a>
Alternative languages
Result language
angličtina
Original language name
Association between endothelial NO synthase polymorphism (rs3918226) and arterial properties
Original language description
In a pilot study, we genotyped 101 untreated subjects (mean age, 54.0 years). Arterial properties were measured using SphygmoCor. We used robust multivariate analysis to assess whether rs3918226 was associated with peripheral or central blood pressure, carotidfemoral pulse wave velocity (PWV) and aortic augmentation index (AIx). As independent covariates we considered sex, age, MAP, heart rate and smoking. Results: Frequencies of rs3918226 genotypes were CC 85.2%, CT 14.8%, and TT 0%. Current smokers carrying mutated T allele had marginally higher PWV (10.0 0.8 vs. 8.7 0.4 m/s; P Z 0.051) and significantly higher AIx (172.2 6.8 vs. 153.2 3.8%; P Z 0.024) compared to CC homozygotes. In non-smokers we did not find any association between rs3918226 and arterial properties (P 0.62). Moreover, we did not observe any association between either peripheral or central blood pressure and the polymorphism under study (P 0.58). Conclusions: This is the first study to explore the association of rs3
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Artery Research
ISSN
1872-9312
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
6
Pages from-to
54-59
UT code for WoS article
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EID of the result in the Scopus database
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