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Transplantation and Stem Cell Therapy for Cerebellar Degenerations

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F16%3A10322599" target="_blank" >RIV/00216208:11140/16:10322599 - isvavai.cz</a>

  • Result on the web

    <a href="http://link.springer.com/article/10.1007/s12311-015-0697-1" target="_blank" >http://link.springer.com/article/10.1007/s12311-015-0697-1</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s12311-015-0697-1" target="_blank" >10.1007/s12311-015-0697-1</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Transplantation and Stem Cell Therapy for Cerebellar Degenerations

  • Original language description

    Stem cell-based and regenerative therapy may become a hopeful treatment for neurodegenerative diseases including hereditary cerebellar degenerations. Neurotransplantation therapy mainly aims to substitute lost cells, but potential effects might include various mechanisms including nonspecific trophic effects and stimulation of endogenous regenerative processes and neural plasticity. Nevertheless, currently, there remain serious limitations. There is a wide spectrum of human hereditary cerebellar degenerations as well as numerous cerebellar mutant mouse strains that serve as models for the development of effective therapy. By now, transplantation has been shown to ameliorate cerebellar function, e.g. in Purkinje cell degeneration mice, Lurcher mutant mice and mouse models of spinocerebellar ataxia type 1 and type 2 and Niemann-Pick disease type C. Despite the lack of direct comparative studies, it appears that there might be differences in graft development and functioning between various types of cerebellar degeneration. Investigation of the relation of graft development to specific morphological, microvascular or biochemical features of the diseased host tissue in various cerebellar degenerations may help to identify factors determining the fate of grafted cells and potential of their functional integration.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FH - Neurology, neuro-surgery, nuero-sciences

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cerebellum

  • ISSN

    1473-4222

  • e-ISSN

  • Volume of the periodical

    15

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    3

  • Pages from-to

    48-50

  • UT code for WoS article

    000371812800012

  • EID of the result in the Scopus database

    2-s2.0-84955672206