Experimental neurotransplantation treatment for hereditary cerebellar ataxias

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F16%3A10325248" target="_blank" >RIV/00216208:11140/16:10325248 - isvavai.cz</a>

Result on the web

<a href="http://cerebellumandataxias.biomedcentral.com/articles/10.1186/s40673-016-0045-3" target="_blank" >http://cerebellumandataxias.biomedcentral.com/articles/10.1186/s40673-016-0045-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s40673-016-0045-3" target="_blank" >10.1186/s40673-016-0045-3</a>

Result language

angličtina

Original language name

Experimental neurotransplantation treatment for hereditary cerebellar ataxias

Original language description

Hereditary cerebellar degenerations are a heterogeneous group of diseases often having a detrimental impact on patients' quality of life. Unfortunately, no sufficiently effective causal therapy is available for human patients at present. There are several therapies that have been shown to affect the pathogenetic process and thereby to delay the progress of the disease in mouse models of cerebellar ataxias. The second experimental therapeutic approach for hereditary cerebellar ataxias is neurotransplantation. Grafted cells might provide an effect via delivery of a scarce neurotransmitter, substitution of lost cells if functionally integrated and rescue or trophic support of degenerating cells. The results of cerebellar transplantation research over the past 30 years are reviewed here and potential benefits and limitations of neurotransplantation therapy are discussed.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cerebellum &amp; Ataxias

ISSN

2053-8871

e-ISSN

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Volume of the periodical

neuveden

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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