ZC3H7B-BCOR high-grade endometrial stromal sarcoma may present as myoma nasces with cytoplasmic signet ring cell change
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F20%3A10410482" target="_blank" >RIV/00216208:11140/20:10410482 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/20:10410482
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4wCjGAUDGU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4wCjGAUDGU</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00428-020-02744-5" target="_blank" >10.1007/s00428-020-02744-5</a>
Alternative languages
Result language
angličtina
Original language name
ZC3H7B-BCOR high-grade endometrial stromal sarcoma may present as myoma nasces with cytoplasmic signet ring cell change
Original language description
Wereporton51-year-oldwomanwhopresentedwithbrowndischargeandpostcoitalbleedingduetomyomanascens-likepolypoid mass distending cervical canal. Histologically, the tumor consisted of high-grade spindle cell component with up to 15 mitotic figures per 10 HPF and also low-grade leiomyoma-like areas with focal myxoid change and so far undescribed cytoplasmic signet ring cell change. Immunohistochemically Desmin, actin, and h-caldesmon were negative. Conversely, BCOR positive expression wascoupledwithCyclinD1positivityandwasantibodyclonedependent.ThemolecularNGSandFISHstudyidentifiedreciprocal fusion gene ZC3H7B-BCOR. In conclusion, these findings further support the idea of routine reflex molecular testing of uterine mesenchymal tumors with unusual clinical presentation or in case malignancy is suspected. Lastly, we suggest ZC3H7B-BCOR rearranged high-grade endometrial stromal sarcoma might be considered as a tumor suitable for BCL6-targeted treatment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Virchows Archiv
ISSN
0945-6317
e-ISSN
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Volume of the periodical
476
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
5
Pages from-to
615-619
UT code for WoS article
000515640800001
EID of the result in the Scopus database
2-s2.0-85077892312