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ZC3H7B-BCOR high-grade endometrial stromal sarcoma may present as myoma nasces with cytoplasmic signet ring cell change

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F20%3A10410482" target="_blank" >RIV/00216208:11140/20:10410482 - isvavai.cz</a>

  • Alternative codes found

    RIV/00669806:_____/20:10410482

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4wCjGAUDGU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4wCjGAUDGU</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00428-020-02744-5" target="_blank" >10.1007/s00428-020-02744-5</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    ZC3H7B-BCOR high-grade endometrial stromal sarcoma may present as myoma nasces with cytoplasmic signet ring cell change

  • Original language description

    Wereporton51-year-oldwomanwhopresentedwithbrowndischargeandpostcoitalbleedingduetomyomanascens-likepolypoid mass distending cervical canal. Histologically, the tumor consisted of high-grade spindle cell component with up to 15 mitotic figures per 10 HPF and also low-grade leiomyoma-like areas with focal myxoid change and so far undescribed cytoplasmic signet ring cell change. Immunohistochemically Desmin, actin, and h-caldesmon were negative. Conversely, BCOR positive expression wascoupledwithCyclinD1positivityandwasantibodyclonedependent.ThemolecularNGSandFISHstudyidentifiedreciprocal fusion gene ZC3H7B-BCOR. In conclusion, these findings further support the idea of routine reflex molecular testing of uterine mesenchymal tumors with unusual clinical presentation or in case malignancy is suspected. Lastly, we suggest ZC3H7B-BCOR rearranged high-grade endometrial stromal sarcoma might be considered as a tumor suitable for BCL6-targeted treatment.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30109 - Pathology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Virchows Archiv

  • ISSN

    0945-6317

  • e-ISSN

  • Volume of the periodical

    476

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    5

  • Pages from-to

    615-619

  • UT code for WoS article

    000515640800001

  • EID of the result in the Scopus database

    2-s2.0-85077892312