Soft tissue sarcoma with ZC3H7B::BCOR fusion in a male mimicking low-grade fibromyxoid sarcoma - A case report
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00079173" target="_blank" >RIV/00159816:_____/23:00079173 - isvavai.cz</a>
Alternative codes found
RIV/61383082:_____/23:00001315 RIV/00216224:14110/23:00133286 RIV/00216208:11110/23:10469566 RIV/00216208:11150/23:10469566 and 2 more
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0344033823005319" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0344033823005319</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.prp.2023.154831" target="_blank" >10.1016/j.prp.2023.154831</a>
Alternative languages
Result language
angličtina
Original language name
Soft tissue sarcoma with ZC3H7B::BCOR fusion in a male mimicking low-grade fibromyxoid sarcoma - A case report
Original language description
Diagnosis of soft tissue tumors is often challenging, given the large number of entities, often with non-specific or overlapping morphology. Although morphology still plays an important part in diagnostic process, additional studies including immunohistochemistry and molecular genetics are often needed to arrive at correct diagnosis. We report a case of 61-year-old male with subcutaneous tumor in right hip area, that was surgically removed. The tumor was composed of uniform bland spindle cells in mild to moderately cellular myxoid nodules, with limited areas of collagenization and the diagnosis of low grade fibromyxoid sarcoma was made. The tumor recurred 3 years after the initial diagnosis and the new sample showed a high-grade round cell sarcoma with limited residual low-grade areas and non-specific immunoprofile after extended immunohistochemical work-up. Molecular analysis demonstrated ZC3H7B::BCOR fusion. Sarcomas with ZC3H7B::BCOR fusion occurring outside of uterus are exceedingly rare. A comprehensive review of previously published cases and a short discussion about classification of the entity is provided, together with data about morphology and immunoprofile of the lesions. The case also underscores the necessity of extended work up of soft tissue tumors with unusual immunohistochemical or morphological features in order to accurately assess their biological potential.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pathology research and practice
ISSN
0344-0338
e-ISSN
1618-0631
Volume of the periodical
251
Issue of the periodical within the volume
NOV 2023
Country of publishing house
DE - GERMANY
Number of pages
5
Pages from-to
154831
UT code for WoS article
001098794100001
EID of the result in the Scopus database
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