Male SIRT1 insufficiency leads to sperm with decreased ability to hyperactivate and fertilize
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F22%3A10445459" target="_blank" >RIV/00216208:11140/22:10445459 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3fkbF-ocKU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3fkbF-ocKU</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/rda.14172" target="_blank" >10.1111/rda.14172</a>
Alternative languages
Result language
angličtina
Original language name
Male SIRT1 insufficiency leads to sperm with decreased ability to hyperactivate and fertilize
Original language description
Deficient sperm motility is a frequent cause of the age-related male sub-/ infertility. Since the protein sirtuin 1 (SIRT1) develops anti-aging action and participates in sperm motility and ATP synthesis in mitochondria, we investigated its role in the acquisition of hyperactivated motility during capacitation. For this, the dynamics of sperm subpopulations were studied, using males of Sirt1+/- heterozygous mutant mice. After 2 hr of capacitation, we observed reduced percentage of hyperactivated spermatozoa in Sirt1+/- males. Interestingly, prior to capacitation, Sirt1+/- spermatozoa showed higher mitochondrial superoxide levels, which could render mitochondrial injury and thereby motility defects. Accordingly, the fertilization rate of Sirt1+/- males after mating was decreased. We elucidated that SIRT1 male insufficiency underlies posterior sperm defects to hyperactivate during capacitation and propose Sirt1+/- males as a model for the study of the age-related infertility.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
<a href="/en/project/EF16_019%2F0000787" target="_blank" >EF16_019/0000787: Fighting INfectious Diseases</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Reproduction in Domestic Animals
ISSN
0936-6768
e-ISSN
1439-0531
Volume of the periodical
57
Issue of the periodical within the volume
S5
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
72-77
UT code for WoS article
000810579100001
EID of the result in the Scopus database
2-s2.0-85131728778