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Inhibition of Acetylcholinesterase in Different Structures of the Rat Brain Following Soman Intoxication Pretreated with Huperzine A

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F07%3A00003648" target="_blank" >RIV/00216208:11150/07:00003648 - isvavai.cz</a>

  • Alternative codes found

    RIV/60162694:G44__/07:00001790 RIV/46747885:24210/07:@KMP0040

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Inhibition of Acetylcholinesterase in Different Structures of the Rat Brain Following Soman Intoxication Pretreated with Huperzine A

  • Original language description

    Acetylcholinesterase activities in different brain parts were determined quantitatively in rats treated with huperzine A, soman, and huperzine A followed by soman, using histochemical and biochemical methods. The results suggest that huperzine A is goodcandidate for further study for clinical use as a prophylactic drug against nerve agent poisoning.

  • Czech name

    Inhibice acetylcholinesterázy v různých strukturách potkaního mozku po intoxikaci somanem předléčené Huperzinem A

  • Czech description

    Aktivita acetylcholinesterázy v různých jádrech potkaního mozku byla stanovována kvantitativně biochemickou a histochemickou metodou po podání huperzinu A, somanu, anebo po použití Huperzinu A před podáním somanu. Výsledky naznačují, že huperzin A je dobrý kandidát pro další studie klinického užití jako profylaktika proti otravě nervově paralytickými jedy.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EA - Morphology and cytology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/OPUOFVZ200603" target="_blank" >OPUOFVZ200603: A new method of prophylaxis, decontamination, diagnostics and therapy afer intoxication with nerve agents and yperits</a><br>

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Molecular Sciences

  • ISSN

    1422-0067

  • e-ISSN

  • Volume of the periodical

    2007

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    12

  • Pages from-to

    1165-1176

  • UT code for WoS article

  • EID of the result in the Scopus database