Zonation of multidrug resistance-associated protein 2 in rat liver after induction with dexamethasone

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F08%3A00106871" target="_blank" >RIV/00216208:11150/08:00106871 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/08:00109220

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Zonation of multidrug resistance-associated protein 2 in rat liver after induction with dexamethasone

Original language description

The study is aimed to evaluate the hepatic zonation of multidrug resistance-associated protein 2 (mrp2), an important drug transporter, and its potential changes during the induction of its expression by known inducer, dexamethasone (DEX). The hepatic expression of mrp2 is studied by immunohistochemistry. Overall changes in mrp2 expression and function produced by DEX are monitored using Western blotting and an in vivo clearance study of endogenous conjugated bilirubin, a mrp2 substrate.

Czech name

Zonace multidrug resistance-associated proteinu 2 v potkaních játrech po indukci dexametazonem

Czech description

Studie je zaměřena na hodnocení zonace mrp2 (multidrug resistance-associated protein 2) transportéru v játrech, a potenciálních změn v jeho expresi během indukce dexametazonem. (DEX). Exprese mrp2 je studována pomocí imunohistochemie. Celkové změny exprese a funkce mrp2 navozené DEX jsou hodnoceny Western blotem a studiem in vivo clearance substrátu mrp2, endogenního konjugovaného bilirubinu.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/1P05OC061" target="_blank" >1P05OC061: Physiologically based prediction of pharmacokinetics prior to in vivo studies: Focus on hepatic and renal drug elimination</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Gastroenterology and Hepatology

ISSN

0815-9319

e-ISSN

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Volume of the periodical

23

Issue of the periodical within the volume

7, Pt. 2

Country of publishing house

AU - AUSTRALIA

Number of pages

6

Pages from-to

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UT code for WoS article

000257756500032

EID of the result in the Scopus database

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