Deteriorating effect of fluvastatin on the cholestatic liver injury induced by bile duct ligation in rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10105732" target="_blank" >RIV/00216208:11150/11:10105732 - isvavai.cz</a>
Alternative codes found
RIV/00216275:25520/11:39892879 RIV/00216208:11160/11:10105732
Result on the web
<a href="http://dx.doi.org/10.4149/gpb_2011_01_66" target="_blank" >http://dx.doi.org/10.4149/gpb_2011_01_66</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/gpb_2011_01_66" target="_blank" >10.4149/gpb_2011_01_66</a>

Result language
angličtina
Original language name
Deteriorating effect of fluvastatin on the cholestatic liver injury induced by bile duct ligation in rats
Original language description
Fluvastatin (1 or 5 mg/kg) was administered after surgery and then daily for 7 days. The dose of 5 mg/kg led to the deterioration of hepatocellular injury. Despite lower production of IL-6, decrease in GSH content, rise of TGFbeta and inhibiton of respiratory complex I in mitochondria were determined. The mRNA expressions of canalicular transporter Mdr1b and basolateral transporter Mrp3 increased in cholestatic liver. Fluvastatin administration then led to the attenuation of this change. Analogously, mRNA expression of cunjugative enzyme Ugt1a1 was diminished by fluvastatin administration to cholestatic rats.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—

Project
<a href="/en/project/NS9739" target="_blank" >NS9739: Can Statins Attenuate a development of cholestatic liver disease?</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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