Ferns and Lycopods - A Potential Treasury of Anticancer Agents but Also a Carcinogenic Hazard

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10188909" target="_blank" >RIV/00216208:11150/14:10188909 - isvavai.cz</a>

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1002/ptr.5070/abstract;jsessionid=CFBFCEBD90D4B8C4FE250B12CF3FC616.f04t03" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/ptr.5070/abstract;jsessionid=CFBFCEBD90D4B8C4FE250B12CF3FC616.f04t03</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ptr.5070" target="_blank" >10.1002/ptr.5070</a>

Result language

angličtina

Original language name

Ferns and Lycopods - A Potential Treasury of Anticancer Agents but Also a Carcinogenic Hazard

Original language description

Many species of seedless vascular plants-ferns and lycopods-have been used as food and folk medicine since ancient times. Some of them have become the focus of intensive research concerning their anticancer properties. Studies on the anticancer effect ofcrude extracts are being increasingly replaced by bioactivity-guided fractionation, as well as detailed assessment of the mechanism of action. Numerous compounds-especially flavonoids such as amentoflavone and protoapigenone, and also simpler phenolic compounds, steroids, alkaloids and terpenoids- were isolated and found to be cytotoxic, particularly pro-apoptotic, or to induce cell cycle arrest in cancer cell lines in vitro. In in vivo experiments, some fern-derived compounds inhibited tumour growth with little toxicity. On the other hand, many ferns-not only the well-known Bracken (Pteridium)-may pose a significant hazard to human health due to the fact that they contain carcinogenic sesquiterpenoids and their analogues. The objectiv

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Phytotherapy Research

ISSN

0951-418X

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

798-810

UT code for WoS article

000337575400002

EID of the result in the Scopus database

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